Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: The Marrow Niche Controls The Cancer Stem Cell Phenotype Of Disseminated Prostate Cancer

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA310191 | ENA |

REPOSITORIES: ENA

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Publications


Dissemination of cancer stem cells (CSCs) serves as the basis of metastasis. Recently, we demonstrated that circulating prostate cancer targets the hematopoietic stem cell (HSCs) 'niche' in marrow during dissemination. Once in the niche, disseminated tumor cells (DTCs) may remain dormant for extended periods. As the major function of the HSC niche is to maintain stem cell functions, we hypothesized that the niche regulates CSC activities of DTCs. Here we show that DTCs recovered from marrow were  ...[more]

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