Dataset Information


Homo sapiens

ABSTRACT: Transcriptomic profiling discloses molecular and cellular events related to neuronal differentiation in SH-SY5Y cells

ORGANISM(S): Homo sapiens  



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Transcriptomic Profiling Discloses Molecular and Cellular Events Related to Neuronal Differentiation in SH-SY5Y Neuroblastoma Cells.

Pezzini Francesco F   Bettinetti Laura L   Di Leva Francesca F   Bianchi Marzia M   Zoratti Elisa E   Carrozzo Rosalba R   Santorelli Filippo M FM   Delledonne Massimo M   Lalowski Maciej M   Simonati Alessandro A  

Cellular and molecular neurobiology 20160715 4

Human SH-SY5Y neuroblastoma cells are widely utilized in in vitro studies to dissect out pathogenetic mechanisms of neurodegenerative disorders. These cells are considered as neuronal precursors and differentiate into more mature neuronal phenotypes under selected growth conditions. In this study, in order to decipher the pathways and cellular processes underlying neuroblastoma cell differentiation in vitro, we performed systematic transcriptomic (RNA-seq) and bioinformatic analysis of SH-SY5Y c  ...[more]

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