Genomics

Dataset Information

118

Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to Nodal/Activin signaling


ABSTRACT: Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to Nodal/Activin signaling

PROVIDER: PRJNA310622 | ENA |

REPOSITORIES: ENA

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Publications

Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to NODAL/Activin signaling.

Coda Davide M DM   Gaarenstroom Tessa T   East Philip P   Patel Harshil H   Miller Daniel S J DS   Lobley Anna A   Matthews Nik N   Stewart Aengus A   Hill Caroline S CS  

eLife 20170213


NODAL/Activin signaling orchestrates key processes during embryonic development via SMAD2. How SMAD2 activates programs of gene expression that are modulated over time however, is not known. Here we delineate the sequence of events that occur from SMAD2 binding to transcriptional activation, and the mechanisms underlying them. NODAL/Activin signaling induces dramatic chromatin landscape changes, and a dynamic transcriptional network regulated by SMAD2, acting via multiple mechanisms. Crucially w  ...[more]

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