Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Affymetrix SNP array data for Trp53-null mammary tumors developed in a mouse model with a K8+ luminal cell origin

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA310636 | ENA |

REPOSITORIES: ENA

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Publications

Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours.

Tao Luwei L   Xiang Dongxi D   Xie Ying Y   Bronson Roderick T RT   Li Zhe Z  

Nature communications 20170213


Most breast cancers may have a luminal origin. TP53 is one of the most frequently mutated genes in breast cancers. However, how p53 deficiency contributes to breast tumorigenesis from luminal cells remains elusive. Here we report that induced p53 loss in Krt8+ mammary luminal cells leads to their clonal expansion without directly affecting their luminal identity. All induced mice develop mammary tumours with 9qA1 (Yap1) and/or 6qA2 (Met) amplification(s). These tumours exhibit a mammary stem cel  ...[more]

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