Dataset Information


Homo sapiens

ABSTRACT: miRNAs expression in HepG2 hepatocellular carcinoma cell lines: Vector Control vs. Twist1, Bcl-2, and Twist1/Bcl-2 Transfected

ORGANISM(S): Homo sapiens  



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Twist1-related miR-26b-5p suppresses epithelial-mesenchymal transition, migration and invasion by targeting SMAD1 in hepatocellular carcinoma.

Wang Yong Y   Sun Baocun B   Zhao Xiulan X   Zhao Nan N   Sun Ran R   Zhu Dongwang D   Zhang Yanhui Y   Li Yanlei Y   Gu Qiang Q   Dong Xueyi X   Wang Meili M   An Jindan J  

Oncotarget 20160401 17

Twist1 is well known to induce epithelial-mesenchymal transition (EMT) and promote tumor metastasis. MicroRNAs (miRNAs) are involved in the EMT process and are associated with metastasis in hepatocellular carcinoma (HCC). In the present study, microRNA-26b-5p (miR-26b-5p) expression was consistently and significantly downregulated in HepG2-Twist1 HCC cell lines compared with HepG2-vector cell lines using microarrays (the HepG2-Twist1 cell line can stably express Twist1). miR-26b- 5p downregulati  ...[more]

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