Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA310644 | ENA |

REPOSITORIES: ENA

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Publications


The majority of hepatocellular carcinoma develops in the background of chronic liver inflammation caused by viral hepatitis and alcoholic or nonalcoholic steatohepatitis. However, the impact of different types of chronic inflammatory microenvironments on the phenotypes of tumors generated by distinct oncogenes is largely unresolved. To address this issue, we generated murine liver tumors by constitutively active AKT-1 (AKT) and β-catenin (CAT), followed by induction of chronic liver inflammation  ...[more]

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