Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: A specialized mechanism of translation mediated by FXR1a-associated microRNP in cellular quiescence

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA310658 | ENA |

REPOSITORIES: ENA

altmetric image

Publications


MicroRNAs predominantly decrease gene expression; however, specific mRNAs are translationally upregulated in quiescent (G0) mammalian cells and immature Xenopus laevis oocytes by an FXR1a-associated microRNA-protein complex (microRNP) that lacks the microRNP repressor, GW182. Their mechanism in these conditions of decreased mTOR signaling, and therefore reduced canonical (cap-and-poly(A)-tail-mediated) translation, remains undiscovered. Our data reveal that mTOR inhibition in human THP1 cells en  ...[more]

Similar Datasets

2012-06-02 | GSE38396 | GEO
2012-06-01 | E-GEOD-38396 | ArrayExpress
2010-09-25 | GSE24338 | GEO
2012-05-20 | BMID000000140905 | BioModels
2010-09-25 | E-GEOD-24338 | ArrayExpress
| GSE63741 | GEO
2010-03-25 | GSE21045 | GEO
| GSE20463 | GEO
| GSE121189 | GEO
2011-02-19 | E-GEOD-20463 | ArrayExpress