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Rattus norvegicus


ABSTRACT: Intralipid protects the heart in late pregnancy against ischemia/reperfusion injury

PROVIDER: PRJNA311228 | ENA |

REPOSITORIES: ENA

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Intralipid protects the heart in late pregnancy against ischemia/reperfusion injury via Caveolin2/STAT3/GSK-3β pathway.

Li Jingyuan J   Ruffenach Gregoire G   Kararigas Georgios G   Cunningham Christine M CM   Motayagheni Negar N   Barakai Neusha N   Umar Soban S   Regitz-Zagrosek Vera V   Eghbali Mansoureh M  

Journal of molecular and cellular cardiology 20161112


<h4>Background</h4>We recently demonstrated that the heart of late pregnant (LP) rodents is more prone to ischemia/reperfusion (I/R) injury compared to non-pregnant rodents. Lipids, particularly polyunsaturated fatty acids, have received special attention in the field of cardiovascular research. Here, we explored whether Intralipid (ITLD) protects the heart against I/R injury in LP rodents and investigated the mechanisms underlying this protection.<h4>Methods and results</h4>In-vivo female LP ra  ...[more]

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