Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: In vivo proteomic expression changes in EW5 Ewing sarcoma xenografts after IGF-1R and/or mTOR blockade

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA312660 | ENA |

REPOSITORIES: ENA

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Publications


BACKGROUND:Therapies cotargeting insulin-like growth factor receptor 1 (IGF-1R) and mammalian target of rapamycin (mTOR) have demonstrated remarkable, albeit short-lived, clinical responses in a subset of Ewing sarcoma (ES) patients. However, the mechanisms of resistance and applicable strategies for overcoming drug resistance to the IGF-1R/mTOR blockade are still undefined. METHODS:To elucidate predominant mechanism(s) of acquired drug resistance while identifying synergistic drug combinations  ...[more]

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