Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Pharmacological Targeting of a Metabolic Co-Dependency Pathway in Brain Cancers

PROVIDER: PRJNA313262 | ENA |

REPOSITORIES: ENA

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Publications


Small-molecule inhibitors targeting growth factor receptors have failed to show efficacy for brain cancers, potentially due to their inability to achieve sufficient drug levels in the CNS. Targeting non-oncogene tumor co-dependencies provides an alternative approach, particularly if drugs with high brain penetration can be identified. Here we demonstrate that the highly lethal brain cancer glioblastoma (GBM) is remarkably dependent on cholesterol for survival, rendering these tumors sensitive to  ...[more]

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