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Homo sapiens

ABSTRACT: Expression data from Nasopharyngeal carcinoma cell SUNE1



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miR-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR-p-PI3K/AKT-c-JUN.

Zhao Mengyang M   Luo Rongcheng R   Liu Yiyi Y   Gao Linyuan L   Fu Zhaojian Z   Fu Qiaofen Q   Luo Xiaojun X   Chen Yiyu Y   Deng Xiaojie X   Liang Zixi Z   Li Xin X   Cheng Chao C   Liu Zhen Z   Fang Weiyi W  

Nature communications 20160420

The biological role of miR-3188 has not yet been reported in the context of cancer. In this study, we observe that miR-3188 not only reduces cell-cycle transition and proliferation, but also significantly prolongs the survival time of tumour-bearing mice as well as sensitizes cells to 5-FU. Mechanistic analyses indicate that miR-3188 directly targets mTOR to inactivate p-PI3K/p-AKT/c-JUN and induces its own expression. This feedback loop further suppresses cell-cycle signalling through the p-PI3  ...[more]

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