Genomics

Dataset Information

118

Mus musculus


ABSTRACT: Signaling couples hair follicle stem cell quiescence with reduced histone H3K4/K9/K27me3 for proper tissue homeostasis

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA313465 | ENA |

REPOSITORIES: ENA

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Publications

Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis.

Lee Jayhun J   Kang Sangjo S   Lilja Karin C KC   Colletier Keegan J KJ   Scheitz Cornelia Johanna Franziska CJ   Zhang Ying V YV   Tumbar Tudorita T  

Nature communications 20160415


Mechanisms of plasticity to acquire different cell fates are critical for adult stem cell (SC) potential, yet are poorly understood. Reduced global histone methylation is an epigenetic state known to mediate plasticity in cultured embryonic SCs and T-cell progenitors. Here we find histone H3 K4/K9/K27me3 levels actively reduced in adult mouse skin and hair follicle stem cells (HFSCs) during G0 quiescence. The level of marks over specific gene promoters did not correlate to mRNA level changes in  ...[more]

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