Project description:BXH/HXB rat recombinant inbred (RI) strains are derived from the spontaneously hypertensive rat (SHR/Ola) and the Brown Norway congenic strains carrying the polydactylyl-luxate mutation (BN-Lx). Tissue from the apex of left ventricle of the heart was disected from 128 RI SHR/Ola and BN-Lx parental strains, RNA was extracted and labelled and hybridised to Affymetrix Rat Genome 230 2.0 Arrays.
Project description:We used Nimblegen HD aCGH to detect copy-number variants between genomes of BN and SHR rats Comparison of single BN against single SHR individual in a dye-swap experiment
Project description:Gene expression data was generated in BN and SHR rats to correlate gene expression differences with CpG methylation differences detected between the strains by whole-genome bisulfite sequencing.
