Dataset Information


Homo sapiens

ABSTRACT: Direct GR binding sites potentiate clusters of TF binding across the human genome [1]

ORGANISM(S): Homo sapiens  



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Direct GR Binding Sites Potentiate Clusters of TF Binding across the Human Genome.

Vockley Christopher M CM   D'Ippolito Anthony M AM   McDowell Ian C IC   Majoros William H WH   Safi Alexias A   Song Lingyun L   Crawford Gregory E GE   Reddy Timothy E TE  

Cell 20160801 5

The glucocorticoid receptor (GR) binds the human genome at >10,000 sites but only regulates the expression of hundreds of genes. To determine the functional effect of each site, we measured the glucocorticoid (GC) responsive activity of nearly all GR binding sites (GBSs) captured using chromatin immunoprecipitation (ChIP) in A549 cells. 13% of GBSs assayed had GC-induced activity. The responsive sites were defined by direct GR binding via a GC response element (GRE) and exclusively increased rep  ...[more]

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2016-08-25 | E-GEOD-79429 | ArrayExpress