Dataset Information


Homo sapiens

ABSTRACT: Expression data from the neuron model of Alzheimer's disease (AD) with or without treatment of recombinant human mitochondrial transcriptional factor A (rhTFAM) protein

ORGANISM(S): Homo sapiens  



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Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease.

Oka Sugako S   Leon Julio J   Sakumi Kunihiko K   Ide Tomomi T   Kang Dongchon D   LaFerla Frank M FM   Nakabeppu Yusaku Y  

Scientific reports 20161129

In the mitochondria-mediated vicious cycle of Alzheimer's disease (AD), intracellular amyloid β (Aβ) induces mitochondrial dysfunction and reactive oxygen species, which further accelerate Aβ accumulation. This vicious cycle is thought to play a pivotal role in the development of AD, although the molecular mechanism remains unclear. Here, we examined the effects of human mitochondrial transcriptional factor A (hTFAM) on the pathology of a mouse model of AD (3xTg-AD), because TFAM is known to pro  ...[more]

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