Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Expression data from the neuron model of Alzheimer's disease (AD) with or without treatment of recombinant human mitochondrial transcriptional factor A (rhTFAM) protein

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA318423 | ENA |

REPOSITORIES: ENA

altmetric image

Publications

Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease.

Oka Sugako S   Leon Julio J   Sakumi Kunihiko K   Ide Tomomi T   Kang Dongchon D   LaFerla Frank M FM   Nakabeppu Yusaku Y  

Scientific reports 20161129


In the mitochondria-mediated vicious cycle of Alzheimer's disease (AD), intracellular amyloid β (Aβ) induces mitochondrial dysfunction and reactive oxygen species, which further accelerate Aβ accumulation. This vicious cycle is thought to play a pivotal role in the development of AD, although the molecular mechanism remains unclear. Here, we examined the effects of human mitochondrial transcriptional factor A (hTFAM) on the pathology of a mouse model of AD (3xTg-AD), because TFAM is known to pro  ...[more]

Similar Datasets

2016-07-20 | E-GEOD-72782 | ArrayExpress
| GSE57152 | GEO
2016-05-09 | MODEL1504240000 | BioModels
| PRJNA318424 | ENA
| GSE80244 | GEO
2016-05-09 | MODEL1504290001 | BioModels
| PRJNA318382 | ENA
| GSE80245 | GEO
2014-04-21 | E-GEOD-48350 | ArrayExpress
2017-01-26 | E-MTAB-4611 | ArrayExpress