Dataset Information


Homo sapiens

ABSTRACT: Transcriptome analysis of H9 hESC derived cerebral organoids

ORGANISM(S): Homo sapiens  



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Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3.

Dang Jason J   Tiwari Shashi Kant SK   Lichinchi Gianluigi G   Qin Yue Y   Patil Veena S VS   Eroshkin Alexey M AM   Rana Tariq M TM  

Cell stem cell 20160506 2

Emerging evidence from the current outbreak of Zika virus (ZIKV) indicates a strong causal link between Zika and microcephaly. To investigate how ZIKV infection leads to microcephaly, we used human embryonic stem cell-derived cerebral organoids to recapitulate early stage, first trimester fetal brain development. Here we show that a prototype strain of ZIKV, MR766, efficiently infects organoids and causes a decrease in overall organoid size that correlates with the kinetics of viral copy number.  ...[more]

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