Dataset Information


Mus musculus

ABSTRACT: Active and inactive enhancers co-operate to exert localized and long-range control of gene regulation [ATAC-seq]

ORGANISM(S): Mus musculus  



altmetric image


Active and Inactive Enhancers Cooperate to Exert Localized and Long-Range Control of Gene Regulation.

Proudhon Charlotte C   Snetkova Valentina V   Raviram Ramya R   Lobry Camille C   Badri Sana S   Jiang Tingting T   Hao Bingtao B   Trimarchi Thomas T   Kluger Yuval Y   Aifantis Iannis I   Bonneau Richard R   Skok Jane A JA  

Cell reports 20160526 10

V(D)J recombination relies on the presence of proximal enhancers that activate the antigen receptor (AgR) loci in a lineage- and stage-specific manner. Unexpectedly, we find that both active and inactive AgR enhancers cooperate to disseminate their effects in a localized and long-range manner. Here, we demonstrate the importance of short-range contacts between active enhancers that constitute an Igk super-enhancer in B cells. Deletion of one element reduces the interaction frequency between othe  ...[more]

Similar Datasets

| PRJNA318456 | ENA
| PRJNA318459 | ENA
| PRJNA318460 | ENA
| PRJNA318457 | ENA
2011-06-24 | E-GEOD-29509 | ArrayExpress
| GSE61911 | GEO
2012-01-24 | E-GEOD-32677 | ArrayExpress
| GSE121443 | GEO
2012-03-29 | E-GEOD-36374 | ArrayExpress
2011-06-02 | E-GEOD-26740 | ArrayExpress