Dataset Information


Mus musculus

ABSTRACT: The aryl hydrocarbon receptor in keratinocytes is essential for murine skin barrier integrity

ORGANISM(S): Mus musculus  



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Aryl Hydrocarbon Receptor in Keratinocytes Is Essential for Murine Skin Barrier Integrity.

Haas Katharina K   Weighardt Heike H   Deenen René R   Köhrer Karl K   Clausen Björn B   Zahner Sonja S   Boukamp Petra P   Bloch Wilhelm W   Krutmann Jean J   Esser Charlotte C  

The Journal of investigative dermatology 20160716 11

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in adaptive cell functions, and it is highly active in the epidermis. AhR ligands can accelerate keratinocyte differentiation, but the precise role of AhR in the skin barrier is unknown. Our study showed that transepidermal water loss, a parameter of skin barrier integrity, is high in AhR-deficient mice. Experiments with conditionally AhR-deficient mouse lines identified keratinocytes as the primary cell popu  ...[more]

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