Dataset Information


Drosophila melanogaster

ABSTRACT: Distinct Enhancer Classes in Drosophila Bind Different Architectural Proteins and Mediate Unique Chromatin Interactions and 3D Architecture [Hi-C]

ORGANISM(S): Drosophila melanogaster  



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Different enhancer classes in Drosophila bind distinct architectural proteins and mediate unique chromatin interactions and 3D architecture.

Cubeñas-Potts Caelin C   Rowley M Jordan MJ   Lyu Xiaowen X   Li Ge G   Lei Elissa P EP   Corces Victor G VG  

Nucleic acids research 20170201 4

Eukaryotic gene expression is regulated by enhancer-promoter interactions but the molecular mechanisms that govern specificity have remained elusive. Genome-wide studies utilizing STARR-seq identified two enhancer classes in Drosophila that interact with different core promoters: housekeeping enhancers (hkCP) and developmental enhancers (dCP). We hypothesized that the two enhancer classes are occupied by distinct architectural proteins, affecting their enhancer-promoter contacts. By evaluating C  ...[more]

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