Breast tumors: different structures of tumor cell
Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: GSE80759
PROVIDER: PRJNA319933 | ENA |
REPOSITORIES: ENA
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Project description:Breast tumors: different structures of tumor cells [cnv]
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Project description:This SuperSeries is composed of the SubSeries listed below.
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Project description:Breast tumors: different structures of tumor cells [gene expression]
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Project description:Tumor associated miRNAs in hereditary breast cancer. In this study we investigated the role of miRNAs in hereditary breast tumors comparing with normal breast tissue. Global miRNA expression profiling was performed on 22 hereditary breast tumors and 15 non-tumoral breast tissues. We identified 19 miRNAs differentially expressed, most of them down-regulated in tumors. An important proportion of deregulated miRNAs in hereditary tumors were previously identified commonly deregulated in sporadic breast tumors. Our results identify miRNAs associated to hereditary breast cancer, as well as miRNAs commonly miss-expressed in hereditary and sporadic tumors, suggesting common underlying mechanisms of tumor progression. In addition, we provide evidence that KRAS is a target of miR-30c, and that this miRNA suppresses breast cancer cell growth potentially through inhibition of KRAS signaling. Single color experiments in a pairwise comparison design.
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