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Distal regulation of c-myb expression during IL-6 induced differentiation in murine myeloid progenitor M1 cells

ABSTRACT: Distal regulation of c-myb expression during IL-6 induced differentiation in murine myeloid progenitor M1 cells

PROVIDER: PRJNA320313 | ENA |

REPOSITORIES: ENA

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Distal regulation of c-myb expression during IL-6 induced differentiation in murine myeloid progenitor M1 cells [4C-seq]

Project description:We report genome-wide long-range interactions of the c-myb promoter in M1 cells.

2017-02-21 | GSE81029 | GEO

Distal regulation of c-myb expression during IL-6 inudced differentiation in murine myeloid progenitor M1 cells [DHS-seq]

Project description:We report DNAase1 hypersensitive sites located upstream of the c-myb gene,associated with gene expression

2017-02-21 | GSE81030 | GEO

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Project description: Not available

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ChIP-on-chip from murine myeloid cell line M1 and virus-induced myeloid leukemia cell lines for H3K4me3, H3K9/14ac, H3K4me1, H3K27me3, H3K9me3 and CTCF

Project description:Histone modifcations and CTCF binding at the c-myb locus were compared in cell lines with c-myb expressing, which are myeloblatic M1 cells and leukemia cells with virus integration, VS. M1 cells without c-myb expression induced by IL-6. Distribution of active histone marks at the c-myb gene and the upstream regions are associated with active c-myb transcription. The enrichment of all of these active histone marks decreased with differentiation-induced down-regulation of c-myb, but increased and spread in tumor cells. ChIP-on-chip from murine myeloid cell line M1 and virus-induced myeloid leukemia cell lines for H3K4me3, H3K9/14ac, H3K4me1, H3K27me3, H3K9me3 and CTCF

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ChIP-on-chip from murine myeloid cell line M1 and virus-induced myeloid leukemia cell lines for H3K4me3, H3K9/14ac, H3K4me1, H3K27me3, H3K9me3 and CTCF

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Distal regulation of c-myb expression during IL-6 induced differentiation in murine myeloid progenitor M1 cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-02-21 | GSE81031 | GEO

Distal regulation of c-myb expression in human myeloid leukemia cells

Project description:The transcription factor c-Myb a key regulator in proliferation and differentiation of hematopoietic progenitor cells, is precisely regulated during essential cellular processes. Overexpression and rearrangement of c-myb has been reported in human tumors including myeloid leukemia, but exact regulatory mechanisms have remained elusive. Here, we identified, using 4C assay with the c-myb promoter as an anchor, the interaction site at -34k region upstream of c-myb gene that are involved in c-myb expression. Furthermore, we found that the long-range interactions changed with c-myb being down-regulated on differentiation progress in human myeloid leukemia cell lines. Taken together, our date revealed that a potential c-myb enhancer-promoter interactions may be a particularly important regulatory mechanism for c-myb gene expression in human myeloid leukemia cells.

2020-11-13 | GSE140321 | GEO

Genome-wide Myb chromatin occupancy in murine myeloid progenitor cells

Project description:We report genome-wide pattern of Myb chromatin occupancy in vivo. We used ERMYB, a myeloid progenitor cell line derived by transformation of primary cells by ER-Myb fusion protein, as our model system. In these cells, activation of the ER-Myb fusion protein by estrogen is required to maintain a proliferative progenitor-like phenotype. We performed ChIP-seq with biological duplicate samples from ERMYB cells with Myb either “on” or “off” (i.e. + or - ?-E2 for 6 hr). By comparing enrichment signals between Myb-on, Myb-off and isotype control samples, we identified 7,646 high-confidence Myb binding regions, which can be assigned to 4,892 annotated genes according to their distances to the nearest transcriptional start sites. Examination of Myb chromatin occupany in myeloid cells transformed by a switchable form of Myb

2011-02-23 | E-GEOD-22095 | biostudies-arrayexpress

Distal regulation of c-myb expression in human myeloid leukemia cells

Project description:Distal regulation of c-myb expression in human myeloid leukemia cells

| PRJNA589290 | ENA

Genome-wide Myb chromatin occupancy in murine myeloid progenitor cells

Project description:We report genome-wide pattern of Myb chromatin occupancy in vivo. We used ERMYB, a myeloid progenitor cell line derived by transformation of primary cells by ER-Myb fusion protein, as our model system. In these cells, activation of the ER-Myb fusion protein by estrogen is required to maintain a proliferative progenitor-like phenotype. We performed ChIP-seq with biological duplicate samples from ERMYB cells with Myb either “on” or “off” (i.e. + or - β-E2 for 6 hr). By comparing enrichment signals between Myb-on, Myb-off and isotype control samples, we identified 7,646 high-confidence Myb binding regions, which can be assigned to 4,892 annotated genes according to their distances to the nearest transcriptional start sites.

2011-02-23 | GSE22095 | GEO

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