Genomics

Dataset Information

118

Homo sapiens


ABSTRACT: Analysis of chromosomal aberrations and recombination by allelic bias in RNA-Seq

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA321469 | ENA |

REPOSITORIES: ENA

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Publications

Analysis of chromosomal aberrations and recombination by allelic bias in RNA-Seq.

Weissbein Uri U   Schachter Maya M   Egli Dieter D   Benvenisty Nissim N  

Nature communications 20160707


Genomic instability has profound effects on cellular phenotypes. Studies have shown that pluripotent cells with abnormal karyotypes may grow faster, differentiate less and become more resistance to apoptosis. Previously, we showed that microarray gene expression profiles can be utilized for the analysis of chromosomal aberrations by comparing gene expression levels between normal and aneuploid samples. Here we adopted this method for RNA-Seq data and present eSNP-Karyotyping for the detection of  ...[more]

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