Dataset Information


Homo sapiens

ABSTRACT: Convergent roles of ATF3 and CSL in chromatin control of CAF activation [HistoneMarkers ChIPseq]

ORGANISM(S): Homo sapiens  



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Convergent roles of ATF3 and CSL in chromatin control of cancer-associated fibroblast activation.

Kim Dong Eun DE   Procopio Maria-Giuseppina MG   Ghosh Soumitra S   Jo Seung-Hee SH   Goruppi Sandro S   Magliozzi Francesco F   Bordignon Pino P   Neel Victor V   Angelino Paolo P   Dotto G Paolo GP  

The Journal of experimental medicine 20170706 8

Cancer-associated fibroblasts (CAFs) are important for tumor initiation and promotion. CSL, a transcriptional repressor and Notch mediator, suppresses CAF activation. Like CSL, ATF3, a stress-responsive transcriptional repressor, is down-modulated in skin cancer stromal cells, and Atf3 knockout mice develop aggressive chemically induced skin tumors with enhanced CAF activation. Even at low basal levels, ATF3 converges with CSL in global chromatin control, binding to few genomic sites at a large  ...[more]

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