Genomics

Dataset Information

118

Mus musculus


ABSTRACT: The Genetic Networks that Orchestrate Development of Specific Waves of Fetal and Adult B-1 and B-2 Development are Distinct

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA321487 | ENA |

REPOSITORIES: ENA

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Publications

Distinct Genetic Networks Orchestrate the Emergence of Specific Waves of Fetal and Adult B-1 and B-2 Development.

Montecino-Rodriguez Encarnacion E   Fice Michael M   Casero David D   Berent-Maoz Beata B   Barber Chad L CL   Dorshkind Kenneth K  

Immunity 20160823 3


B cell development is often depicted as a linear process initiating in the fetus and continuing postnatally. Using a PU.1 hypomorphic mouse model, we found that B-1 and B-2 lymphopoiesis occurred in distinct fetal and adult waves differentially dependent on the Sfpi1 14 kB upstream regulatory element. The initial wave of fetal B-1 development was absent in PU.1 hypomorphic mice, while subsequent fetal and adult waves emerged. In contrast, B-2 lymphopoiesis occurred in distinct fetal and adult wa  ...[more]

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