Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: LMP1+SLAMF1high cells are associated with drug resistance in Epstein-Barr virus-positive Farage cells

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA321496 | ENA |

REPOSITORIES: ENA

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Publications

LMP1+SLAMF1high cells are associated with drug resistance in Epstein-Barr virus-positive Farage cells.

Yoon Heejei H   Ko Young Hyeh YH  

Oncotarget 20170401 15


How Epstein-Barr virus (EBV) affects the clinical outcome of EBV-positive diffuse large B-cell lymphoma (DLBCL) remains largely unknown. The viral oncogene LMP1 is at the crux of tumorigenesis and cell survival. Therefore, we examined the association between LMP1high cells drug resistance. We first assessed SLAMF1 as a surrogate marker for LMP1high cells. LMP1 and its target gene CCL22 were highly expressed in SLAMF1high Farage cells. These cells survived longer following treatment with a combin  ...[more]

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