Genomics

Dataset Information

0

Mus musculus


ABSTRACT: B cell development requires discrete regulation by PTEN-PI3K and mTOR pathways and the intricate interplay with IL-7 r-Stat5 signaling

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA322694 | ENA |

REPOSITORIES: ENA

altmetric image

Publications

Discrete roles and bifurcation of PTEN signaling and mTORC1-mediated anabolic metabolism underlie IL-7-driven B lymphopoiesis.

Zeng Hu H   Yu Mei M   Tan Haiyan H   Li Yuxin Y   Su Wei W   Shi Hao H   Dhungana Yogesh Y   Guy Cliff C   Neale Geoffrey G   Cloer Caryn C   Peng Junmin J   Wang Demin D   Chi Hongbo H  

Science advances 20180131 1


Interleukin-7 (IL-7) drives early B lymphopoiesis, but the underlying molecular circuits remain poorly understood, especially how Stat5 (signal transducer and activator of transcription 5)-dependent and Stat5-independent pathways contribute to this process. Combining transcriptome and proteome analyses and mouse genetic models, we show that IL-7 promotes anabolic metabolism and biosynthetic programs in pro-B cells. IL-7-mediated activation of mTORC1 (mechanistic target of rapamycin complex 1) su  ...[more]

Similar Datasets

2018-02-14 | GSE81844 | GEO
2018-01-01 | S-EPMC5792226 | BioStudies
1000-01-01 | S-EPMC3949578 | BioStudies
2011-01-01 | S-EPMC3225010 | BioStudies
2009-01-01 | S-EPMC2694984 | BioStudies
1000-01-01 | S-EPMC5029739 | BioStudies
2011-01-01 | S-EPMC3260807 | BioStudies
2013-01-01 | S-EPMC4130654 | BioStudies
2016-01-01 | S-EPMC5173143 | BioStudies
1000-01-01 | S-EPMC4058012 | BioStudies