Dataset Information


Mus musculus

ABSTRACT: B cell development requires discrete regulation by PTEN-PI3K and mTOR pathways and the intricate interplay with IL-7 r-Stat5 signaling

ORGANISM(S): Mus musculus  



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Discrete roles and bifurcation of PTEN signaling and mTORC1-mediated anabolic metabolism underlie IL-7-driven B lymphopoiesis.

Zeng Hu H   Yu Mei M   Tan Haiyan H   Li Yuxin Y   Su Wei W   Shi Hao H   Dhungana Yogesh Y   Guy Cliff C   Neale Geoffrey G   Cloer Caryn C   Peng Junmin J   Wang Demin D   Chi Hongbo H  

Science advances 20180131 1

Interleukin-7 (IL-7) drives early B lymphopoiesis, but the underlying molecular circuits remain poorly understood, especially how Stat5 (signal transducer and activator of transcription 5)-dependent and Stat5-independent pathways contribute to this process. Combining transcriptome and proteome analyses and mouse genetic models, we show that IL-7 promotes anabolic metabolism and biosynthetic programs in pro-B cells. IL-7-mediated activation of mTORC1 (mechanistic target of rapamycin complex 1) su  ...[more]

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