Genomics

Dataset Information

235

Genome-wide maps of histone variant H3.3 occupancy in zebrafish cardiomyocytes


ABSTRACT: Genome-wide maps of histone variant H3.3 occupancy in zebrafish cardiomyocytes

PROVIDER: PRJNA323351 | ENA |

REPOSITORIES: ENA

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Publications


Chromatin regulation is a principal mechanism governing animal development, yet it is unclear to what extent structural changes in chromatin underlie tissue regeneration. Non-mammalian vertebrates such as zebrafish activate cardiomyocyte (CM) division after tissue damage to regenerate lost heart muscle. Here, we generated transgenic zebrafish expressing a biotinylatable H3.3 histone variant in CMs and derived cell-type-specific profiles of histone replacement. We identified an emerging program o  ...[more]

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