Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Epithelial Splicing Regulatory protein 1 promotes human colorectal cancer cell growth and metastasis

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA323353 | ENA |

REPOSITORIES: ENA

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Publications


Epithelial splicing regulatory protein 1 (ESRP1) is an epithelial cell-specific RNA binding protein that controls several key cellular processes, like alternative splicing and translation. Previous studies have demonstrated a tumor suppressor role for this protein. Recently, however, a pro-metastatic function of ESRP1 has been reported. We thus aimed at clarifying the role of ESRP1 in Colorectal Cancer (CRC) by performing loss- and gain-of-function studies, and evaluating tumorigenesis and malig  ...[more]

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