Genomics

Dataset Information

0

Rattus norvegicus


ABSTRACT: microRNA data from atrophied rat gastrocnemius of 5 days post denervation versus sham control

ORGANISM(S): Rattus norvegicus  

PROVIDER: PRJNA323420 | ENA |

REPOSITORIES: ENA

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Publications


A number of microRNAs (miRNAs, miRs) have been shown to play a role in skeletal muscle atrophy, but their role is not completely understood. Here we show that miR-29b promotes skeletal muscle atrophy in response to different atrophic stimuli in cells and in mouse models. miR-29b promotes atrophy of myotubes differentiated from C2C12 or primary myoblasts, and conversely, its inhibition attenuates atrophy induced by dexamethasone (Dex), TNF-α and H2O2 treatment. Targeting of IGF-1 and PI3K(p85α) b  ...[more]

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