Genomics

Dataset Information

139

Prep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis


ABSTRACT: Prep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis

PROVIDER: PRJNA324117 | ENA |

REPOSITORIES: ENA

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Prep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis.

Dardaei Leila L   Longobardi Elena E   Blasi Francesco F  

Proceedings of the National Academy of Sciences of the United States of America 20140227 10


Pbx-regulating protein-1 (Prep1) is a tumor suppressor, whereas myeloid ecotropic viral integration site-1 (Meis1) is an oncogene. We show that, to perform these activities in mouse embryonic fibroblasts, both proteins competitively heterodimerize with pre-B-cell leukemia homeobox-1 (Pbx1). Meis1 alone transforms Prep1-deficient fibroblasts, whereas Prep1 overexpression inhibits Meis1 tumorigenicity. Pbx1 can, therefore, alternatively act as an oncogene or tumor suppressor. Prep1 posttranslation  ...[more]

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