Dataset Information


Homo sapiens

ABSTRACT: Epigenetic regulation of the transcriptional program in memory and terminally differentiated CD8+ T cells [HCAFIS_03_ChIPseq]

ORGANISM(S): Homo sapiens  



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Epigenetic Networks Regulate the Transcriptional Program in Memory and Terminally Differentiated CD8+ T Cells.

Rodriguez Ramon M RM   Suarez-Alvarez Beatriz B   Lavín José L JL   Mosén-Ansorena David D   Baragaño Raneros Aroa A   Márquez-Kisinousky Leonardo L   Aransay Ana M AM   Lopez-Larrea Carlos C  

Journal of immunology (Baltimore, Md. : 1950) 20161214 2

Epigenetic mechanisms play a critical role during differentiation of T cells by contributing to the formation of stable and heritable transcriptional patterns. To better understand the mechanisms of memory maintenance in CD8+ T cells, we performed genome-wide analysis of DNA methylation, histone marking (acetylated lysine 9 in histone H3 and trimethylated lysine 9 in histone), and gene-expression profiles in naive, effector memory (EM), and terminally differentiated EM (TEMRA) cells. Our results  ...[more]

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