Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Dynamic regulation of chromatin signatures during Drosophila embryonic glial differentiation

ABSTRACT: Dynamic regulation of chromatin signatures during Drosophila embryonic glial differentiation

PROVIDER: PRJNA325731 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Dynamic regulation of chromatin signatures during Drosophila embryonic glial differentiation [ChIP-Seq]

Project description:Employ affinity purification approach to capture different stages of glial-specific information on gene expression, nucleosome occupancy and histone modifications (HMs) in Drosophila melanogaster embryo

2016-11-20 | GSE83376 | GEO

Dynamic regulation of chromatin signatures during Drosophila embryonic glial differentiation [RNA-Seq]

Project description:Expression profiles of affinity-purified nuclei of GBs and glias from the Drosophila embryos.

2016-11-20 | GSE83375 | GEO

Dynamic regulation of chromatin signatures during Drosophila embryonic glial differentiation

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-11-20 | GSE83377 | GEO

Drosophila CNS glial microarray

Project description:Gliogenesis in the Drosophila CNS occurs during embryogenesis and also during the postembryonic larval stages. Several glial subtypes are generated in the postembryonic CNS through the proliferation of differentiated glial cells. The genes and molecular pathways that regulate glial proliferation in the postembryonic CNS are poorly understood. In this study we aimed to use gene expressing profiling of CNS tissue enriched in glia to identify genes expressed in glial cells in the postembryonic CNS. We used microarrays to compare the gene expression profiles from the larval CNS of animals that had increased numbers of glial cells to identify genes that are expressed in glia. RNA was purified from the late third instar larval CNS from control larvae, or larvae expressing an activated form of the FGF receptor (Hlt[ACT]), or overexpressing the insulin receptor (InR) in glial cells using the glial specific driver repoGal4 to increase the number of glial cells and generate CNS tissue enriched in glia.

2013-04-24 | E-GEOD-46317 | biostudies-arrayexpress

Drosophila CNS glial microarray

2013-04-24 | GSE46317 | GEO

Drosophila melanogaster

Project description:Dynamic regulation of chromatin signatures during Drosophila embryonic glial differentiation [RNA-Seq]

| PRJNA325734 | ENA

Drosophila melanogaster

Project description:Dynamic regulation of chromatin signatures during Drosophila embryonic glial differentiation [ChIP-Seq]

| PRJNA325733 | ENA

Atopic dermatitis displays stable and dynamic skin transcriptome signatures

Project description:Atopic dermatitis displays stable and dynamic skin transcriptome signatures

| PRJNA660423 | ENA

Dynamic epigenetic enhancer signatures are predictive for key transcriptional regulators associated with cellular differentiation states

Project description:Cellular differentiation is orchestrated by lineage-specific transcription factors and associates with cell type-specific epigenetic signatures. Here, we utilized stage-specific, epigenetic "fingerprints" to deduce key transcriptional regulators of a cellular differentiation process. In the model of human macrophage differentiation, we globally mapped the distribution of epigenetic enhancer marks (histone H3 lysine 4 monomethylation, histone H3 lysine 27 acetylation, and the histone variant H2AZ) and show that cell type-specific epigenetic "fingerprints" correlate with specific, de novo derived motif signatures at all differentiation stages studied (hematopoietic progenitor cell, monocyte, macrophage). We validated the novel, de novo derived, macrophage-specific enhancer signature which included ETS, CEBP, bZIP, EGR, E-Box and NFkB motifs by ChIP-sequencing for a subset of motif corresponding transcription factors (PU.1, C/EBPbeta, and EGR2) which confirmed their predicted association with differentiation-associated epigenetic changes. This study highlights the power of genome-wide epigenetic profiling studies to reveal novel functional insights. It describes the dynamic enhancer landscape of human macrophage differentiation and provides a unique resource for macrophage biologists. ChIP-seq of 3 histone marks and 3 transcription factors in human blood monocytes and macrophages

2012-05-02 | E-GEOD-31621 | biostudies-arrayexpress

hESC-based human glial chimeric mice reveal glial differentiation defects in Huntington disease

Project description:hESC-based human glial chimeric mice reveal glial differentiation defects in Huntington disease

| PRJNA414457 | ENA