Genomics

Dataset Information

118

Homo sapiens


ABSTRACT: N6-methyladenosine in Flaviviridae viral RNA genomes regulates infection

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA325928 | ENA |

REPOSITORIES: ENA

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Publications


The RNA modification N6-methyladenosine (m6A) post-transcriptionally regulates RNA function. The cellular machinery that controls m6A includes methyltransferases and demethylases that add or remove this modification, as well as m6A-binding YTHDF proteins that promote the translation or degradation of m6A-modified mRNA. We demonstrate that m6A modulates infection by hepatitis C virus (HCV). Depletion of m6A methyltransferases or an m6A demethylase, respectively, increases or decreases infectious  ...[more]

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