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Local lung hypoxia determines epithelial fate decisions during alveolar regeneration

ABSTRACT: Local lung hypoxia determines epithelial fate decisions during alveolar regeneration

PROVIDER: PRJNA326204 | ENA |

REPOSITORIES: ENA

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Local lung hypoxia determines epithelial fate decisions during alveolar regeneration.

Project description: Not available

| S-EPMC5600325 | biostudies-literature

Local lung hypoxia determines epithelial fate decisions during alveolar regeneration

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-06-20 | GSE83505 | GEO

Human Single Cells - Local lung hypoxia determines epithelial fate decisions during alveolar regeneration

Project description:Single human lung epithelial cell transcriptomes, isolated and processed via Fluidigm C1

2017-06-20 | GSE83501 | GEO

Mouse pooled LNEPs, pre- and post-influenza - Local lung hypoxia determines epithelial fate decisions during alveolar regeneration

Project description:Flow sorted mouse LNEP cells isolated from normal lungs and influenza-infected lungs (day 17 PR8)

2017-06-20 | GSE83467 | GEO

Alveolar lavage fluid of Guizhou local piglets

Project description:Alveolar lavage fluid of Guizhou local piglets Metagenome

| PRJNA576744 | ENA

Homo sapiens

Project description:Human Single Cells - Local lung hypoxia determines epithelial fate decisions during alveolar regeneration

| PRJNA326167 | ENA

Klf5 promotes alveolar epithelial type 1 cell lineage commitment during lung development and regeneration

Project description:Alveolar epithelial cell fate decisions drive lung development and regeneration. Using transcriptomic and epigenetic profiling coupled with genetic mouse and organoid models, we identified Klf5 as a critical regulator of alveolar epithelial cell fate across the lifespan. During prenatal lung development and alveologenesis, Klf5 enforces alveolar epithelial type 1 (AT1) cell lineage fidelity. While it is dispensable for both adult AT1 and alveolar epithelial type 2 (AT2) cell homeostasis, Klf5 regulates AT2 cell plasticity after injury. Klf5 represses AT2 cell proliferation and enhances AT2-AT1 cell differentiation in a spatially restricted manner in both infectious and non-infectious models of acute respiratory distress syndrome. Moreover, ex vivo organoid assays reveal that Klf5 modulates AT2 cell fate decisions through reducing AT2 cell sensitivity to inflammatory signaling. These data highlight a major transcriptional regulator of AT1 cell lineage commitment and of the AT2 cell response to inflammatory crosstalk during lung regeneration.

2022-06-08 | GSE190676 | GEO

Spatial alanine metabolism determines local growth dynamics of Escherichia coli colonies

Project description:Spatial alanine metabolism determines local growth dynamics of Escherichia coli colonies

| PRJNA733507 | ENA

Hypoxia-inducible factor-2 (HIF2) regulates alveolar regeneration after repetitive injury

Project description:Idiopathic Pulmonary Fibrosis (IPF) is a progressive and often fatal chronic respiratory disease thought to result from repetitive injury and failed repair of the lung alveoli, and recent studies have identified a number of disease-emergent intermediate/transitional cell states in the IPF lung supporting this concept. In this study, we found that persistent activation of hypoxia-inducible factor (HIF)-signaling in airway-derived, repair-associated cell types/states is a hallmark of dysfunctional epithelial repair in the IPF lung epithelium and experimental models of recurrent lung epithelial injury. Disrupting Hif-signaling attenuated experimental lung fibrosis, reduced mucous-secretory cell polarization, and promoted functional alveolar regeneration following repetitive injury. Mouse and human organoid studies demonstrated that small-molecule-based HIF2 inhibition promoted alveolar epithelial cell proliferation and maturation while preventing the emergence of maladaptive intermediate/transitional states analogous to those in IPF. Together, these studies indicate that targeted HIF2-inhibition represents a novel and effective therapeutic strategy to promote functional lung regeneration, and could be readily translated into human studies of IPF and other chronic interstitial lung diseases with disease modifying effect.

2023-09-18 | GSE243252 | GEO

Mus musculus

Project description:Mouse pooled LNEPs, pre- and post-influenza - Local lung hypoxia determines epithelial fate decisions during alveolar regeneration

| PRJNA326070 | ENA

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