Dataset Information


Mus musculus

ABSTRACT: Genome-wide analysis of LPS-responsive gene expression by microglia cells in Ntg and LRRK2KO mouse brain

ORGANISM(S): Mus musculus  



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LRRK2 modulates microglial activity through regulation of chemokine (C-X3-C) receptor 1 -mediated signalling pathways.

Ma Bo B   Xu Leyan L   Pan Xiaodong X   Sun Lixin L   Ding Jinhui J   Xie Chengsong C   Koliatsos Vassilis E VE   Cai Huaibin H  

Human molecular genetics 20160704 16

Multiple missense mutations in Leucine-rich repeat kinase 2 (LRRK2) have been linked to Parkinson's disease (PD), the most common degenerative movement disorder. LRRK2 is expressed by both neurons and microglia, the residential immune cells in the brain. Increasing evidence supports a role of LRRK2 in modulating microglial activity, of which Lrrk2-null rodent microglia display less inflammatory response to endotoxin lipopolysaccharide (LPS). The underlying molecular mechanism, however, remains e  ...[more]

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