Genomics

Dataset Information

118

Mus musculus


ABSTRACT: RNA-sequencing of Fes KO and WT melanomas

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA326413 | ENA |

REPOSITORIES: ENA

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Publications


Identification and functional validation of oncogenic drivers are essential steps toward advancing cancer precision medicine. Here, we have presented a comprehensive analysis of the somatic genomic landscape of the widely used BRAFV600E- and NRASQ61K-driven mouse models of melanoma. By integrating the data with publically available genomic, epigenomic, and transcriptomic information from human clinical samples, we confirmed the importance of several genes and pathways previously implicated in hu  ...[more]

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