Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Patient derived melanoma xenografts

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA326418 | ENA |

REPOSITORIES: ENA

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Publications


New therapies are required for melanoma. Here, we report that multiple cardiac glycosides, including digitoxin and digoxin, are significantly more toxic to human melanoma cells than normal human cells. This reflects on-target inhibition of the ATP1A1 Na(+)/K(+) pump, which is highly expressed by melanoma. MEK inhibitor and/or BRAF inhibitor additively or synergistically combined with digitoxin to induce cell death, inhibiting growth of patient-derived melanomas in NSG mice and synergistically ex  ...[more]

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