Dataset Information


Homo sapiens

ABSTRACT: Oncoscan for HER2 copy number assessment

ORGANISM(S): Homo sapiens  



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Precise ERBB2 copy number assessment in breast cancer by means of molecular inversion probe array analysis.

Christgen Matthias M   van Luttikhuizen Jana L JL   Raap Mieke M   Braubach Peter P   Schmidt Lars L   Jonigk Danny D   Feuerhake Friedrich F   Lehmann Ulrich U   Schlegelberger Brigitte B   Kreipe Hans H HH   Steinemann Doris D  

Oncotarget 20161201 50

HER2/ERBB2 amplification/overexpression determines the eligibility of breast cancer patients to HER2-targeted therapy. This study evaluates the agreement between ERBB2 copy number assessment by fluorescence in situ hybridization, a standard method recommended by the American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP), and newly available DNA extraction-based methods. A series of n=29 formalin-fixed paraffin-embedded breast cancers were subjected to ERBB2 copy number  ...[more]

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