Genomics

Dataset Information

118

Mus musculus


ABSTRACT: Reconstructing blood stem cell regulatory network models from single-cell molecular profiles

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA328869 | ENA |

REPOSITORIES: ENA

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Publications

Reconstructing blood stem cell regulatory network models from single-cell molecular profiles.

Hamey Fiona K FK   Nestorowa Sonia S   Kinston Sarah J SJ   Kent David G DG   Wilson Nicola K NK   Göttgens Berthold B  

Proceedings of the National Academy of Sciences of the United States of America 20170601 23


Adult blood contains a mixture of mature cell types, each with specialized functions. Single hematopoietic stem cells (HSCs) have been functionally shown to generate all mature cell types for the lifetime of the organism. Differentiation of HSCs toward alternative lineages must be balanced at the population level by the fate decisions made by individual cells. Transcription factors play a key role in regulating these decisions and operate within organized regulatory programs that can be modeled  ...[more]

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