Project description:In this experiment, we used four diets, one based on FM, a challenging diet with 40% soybean meal (SBM), and two diets containing 40% SBM with 5% of Cyberlindnera jadinii yeast exposed to different down-stream processing conditions (heat-inactivated or autolysation). The immunomodulatory effects of the diets were analyzed in the spleen of Atlantic salmon after 37 days of feeding. The results showed that the inclusion of autolysed C. jadinii (ACJ) was able to modulate the response of Atlantic salmon compared to fish fed the SBM-diet, through the activation of biological pathways related to endocytosis, PPRs-signal transduction and transporter activity. Finally, we suggest that the spleen is a good candidate to characterize the immunomodulatory effects of functional ingredients in Atlantic salmon.

2021-08-12 | GSE174262 | GEO

Cyberlindnera jadinii NRRL Y-1542 isolate:NRRL Y-1542

Project description:Cyberlindnera jadinii NRRL Y-1542 EST - Xylose transcriptome

| PRJNA494745 | ENA

Cyberlindnera jadinii NRRL Y-1542 isolate:NRRL Y-1542

Project description:Cyberlindnera jadinii NRRL Y-1542 EST - Glucose transcriptome

| PRJNA494746 | ENA

Cyberlindnera jadinii yeast as a functional protein source: Modulation of immunoregulatory pathways in the intestinal proteome of zebrafish (Danio rerio)

Project description:Cyberlindnera jadinii yeast is a potential sustainable novel feed ingredient for aquaculture industries. Yeasts contain bio-active components and proteins such as beta-glucans, mannans, nucleic acids and proteins that can enhance fish immunity against the disease. In our study, we focused on the characterization of intestinal immunoregulatory pathways in zebrafish (Danio rerio) by quantifying the intestine proteins with isobaric tags for relative and absolute quantitation (iTRAQ) and 2D LC-MS/MS approach. Zebrafish were fed either a control diet (C) or a diet supplemented with autolyzed C. jadinii (ACJ). The KEGG pathways analysis revealed that compared with the control diet, the ACJ yeast diet induced an increased abundance of proteins related to arginine and proline metabolism, phagosome, C-lectin receptor signalling pathway, ribosome pathway and PPAR signalling pathway, which can modulate and enhance the innate response of zebrafish. Moreover, fish fed ACJ yeast diet also showed decreased abundance of proteins associated with inflammatory pathways including apoptosis, necroptosis and ferroptosis pathways. These findings support a mobilization of the innate immune response and a control of inflammatory-related pathways in the intestine of zebrafish. Our findings in the well annotated proteome of zebrafish enabled a detailed investigation of intestinal responses and provide insight into the health-beneficial effects of the yeast species C. jadinii relevant for aquaculture species.

2024-05-24 | PXD040431 | Pride

Aureobasidium pullulans strain:CCTCC M2012223

Project description:Aureobasidium pullulans strain:CCTCC M2012223 Raw sequence reads

| PRJNA301913 | ENA

Aspergillus carbonarius strain:CCTCC AF 2011004

Project description:Aspergillus carbonarius strain:CCTCC AF 2011004 Raw sequence reads

| PRJNA593878 | ENA

cjadinii_genome

Project description:Cyberlindnera jadinii genome assembly

| PRJEB7977 | ENA