Dataset Information


Staphylococcus aureus

ABSTRACT: Effect of benzimidazole derivative C162 on Staphylococcus aureus virulence

ORGANISM(S): Staphylococcus aureus  



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Suppression of Staphylococcus aureus biofilm formation and virulence by a benzimidazole derivative, UM-C162.

Kong Cin C   Chee Chin-Fei CF   Richter Katharina K   Thomas Nicky N   Abd Rahman Noorsaadah N   Nathan Sheila S  

Scientific reports 20180209 1

Staphylococcus aureus is a major cause of nosocomial infections and secretes a diverse spectrum of virulence determinants as well as forms biofilm. The emergence of antibiotic-resistant S. aureus highlights the need for alternative forms of therapeutics other than conventional antibiotics. One route to meet this need is screening small molecule derivatives for potential anti-infective activity. Using a previously optimized C. elegans - S. aureus small molecule screen, we identified a benzimidazo  ...[more]

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