Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Pre-processing method comparison on Illumina HumanMethylation450 BeadChips array

PROVIDER: PRJNA329483 | ENA |

REPOSITORIES: ENA

altmetric image

Publications

Comparison of pre-processing methods for Infinium HumanMethylation450 BeadChip array.

Shiah Yu-Jia YJ   Fraser Michael M   Bristow Robert G RG   Boutros Paul C PC  

Bioinformatics (Oxford, England) 20171001 20


<h4>Motivation</h4>Microarrays are widely used to quantify DNA methylation because they are economical, require only small quantities of input DNA and focus on well-characterized regions of the genome. However, pre-processing of methylation microarray data is challenging because of confounding factors that include background fluorescence, dye bias and the impact of germline polymorphisms. Therefore, we present valuable insights and a framework for those seeking the most optimal pre-processing me  ...[more]

Similar Datasets

| E-GEOD-59796 | BioStudies
| E-GEOD-42752 | BioStudies
| E-GEOD-55571 | BioStudies
| E-TABM-1169 | BioStudies
| S-EPMC2668177 | BioStudies
| E-GEOD-45707 | BioStudies
| E-GEOD-63849 | BioStudies
| E-GEOD-43293 | BioStudies
| E-GEOD-54399 | BioStudies
| E-GEOD-71837 | BioStudies