Genomics

Dataset Information

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Microarray analysis of CD9high and CD9low progenitors isolated from adipose tissue


ABSTRACT: Microarray analysis of CD9high and CD9low progenitors isolated from adipose tissue

PROVIDER: PRJNA331205 | ENA |

REPOSITORIES: ENA

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Publications


Obesity-induced white adipose tissue (WAT) fibrosis is believed to accelerate WAT dysfunction. However, the cellular origin of WAT fibrosis remains unclear. Here, we show that adipocyte platelet-derived growth factor receptor-α-positive (PDGFRα+) progenitors adopt a fibrogenic phenotype in obese mice prone to visceral WAT fibrosis. More specifically, a subset of PDGFRα+ cells with high CD9 expression (CD9high) originates pro-fibrotic cells whereas their CD9low counterparts, committed to adipogen  ...[more]

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