Genomics

Dataset Information

59

Dido as a switchboard that regulates self-renewal and differentiation in embryonic stem cells


ABSTRACT: Dido as a switchboard that regulates self-renewal and differentiation in embryonic stem cells

PROVIDER: PRJNA335995 | ENA |

REPOSITORIES: ENA

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Publications


Transition from symmetric to asymmetric cell division requires precise coordination of differential gene expression. We show that embryonic stem cells (ESCs) mainly express DIDO3 and that their differentiation after leukemia inhibitory factor withdrawal requires DIDO1 expression. C-terminal truncation of DIDO3 (Dido3ΔCT) impedes ESC differentiation while retaining self-renewal; small hairpin RNA-Dido1 ESCs have the same phenotype. Dido3ΔCT ESC differentiation is rescued by ectopic expression of  ...[more]

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