Genomics

Dataset Information

118

Mus musculus


ABSTRACT: Global accessibility of mitotic chromosomes

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA336477 | ENA |

REPOSITORIES: ENA

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Publications

A dynamic mode of mitotic bookmarking by transcription factors.

Teves Sheila S SS   An Luye L   Hansen Anders S AS   Xie Liangqi L   Darzacq Xavier X   Tjian Robert R  

eLife 20161119


During mitosis, transcription is shut off, chromatin condenses, and most transcription factors (TFs) are reported to be excluded from chromosomes. How do daughter cells re-establish the original transcription program? Recent discoveries that a select set of TFs remain bound on mitotic chromosomes suggest a potential mechanism for maintaining transcriptional programs through the cell cycle termed mitotic bookmarking. Here we report instead that many TFs remain associated with chromosomes in mouse  ...[more]

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