Genomics

Dataset Information

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Trypanosoma brucei


ABSTRACT: Transcriptome and proteome analyses and the role of atypical calpain protein and autophagy in the spliced leader silencing pathway in Trypanosoma brucei

ORGANISM(S): Trypanosoma brucei  

PROVIDER: PRJNA339044 | ENA |

REPOSITORIES: ENA

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Transcriptome and proteome analyses and the role of atypical calpain protein and autophagy in the spliced leader silencing pathway in Trypanosoma brucei.

Hope Ronen R   Egarmina Katarina K   Voloshin Konstantin K   Waldman Ben-Asher Hiba H   Carmi Shai S   Eliaz Dror D   Drori Yaron Y   Michaeli Shulamit S  

Molecular microbiology 20160831 1


Under persistent ER stress, Trypanosoma brucei parasites induce the spliced leader silencing (SLS) pathway. In SLS, transcription of the SL RNA gene, the SL donor to all mRNAs, is extinguished, arresting trans-splicing and leading to programmed cell death (PCD). In this study, we investigated the transcriptome following silencing of SEC63, a factor essential for protein translocation across the ER membrane, and whose silencing induces SLS. The proteome of SEC63-silenced cells was analyzed with a  ...[more]

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