Dataset Information


Mus musculus

ABSTRACT: TET proteins regulate lineage specification and TCR-mediated expansion of iNKT cells (SMART-Seq)

ORGANISM(S): Mus musculus  



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TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells.

Tsagaratou Ageliki A   González-Avalos Edahí E   Rautio Sini S   Scott-Browne James P JP   Togher Susan S   Pastor William A WA   Rothenberg Ellen V EV   Chavez Lukas L   Lähdesmäki Harri H   Rao Anjana A  

Nature immunology 20161121 1

TET proteins oxidize 5-methylcytosine in DNA to 5-hydroxymethylcytosine and other oxidation products. We found that simultaneous deletion of Tet2 and Tet3 in mouse CD4+CD8+ double-positive thymocytes resulted in dysregulated development and proliferation of invariant natural killer T cells (iNKT cells). Tet2-Tet3 double-knockout (DKO) iNKT cells displayed pronounced skewing toward the NKT17 lineage, with increased DNA methylation and impaired expression of genes encoding the key lineage-specifyi  ...[more]

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