Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Gene expression in hepatocytes isolated from diet-induced obesity mice treated with anti-VLA-4 blocking antibody.

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA339049 | ENA |

REPOSITORIES: ENA

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Publications


Obesity promotes infiltration of inflammatory cells into various tissues, leading to parenchymal and stromal cell interaction and development of cellular and organ dysfunction. Liver sinusoidal endothelial cells (LSECs) are the first cells that contact portal blood cells and substances in the liver, but their functions in the development of obesity-associated glucose metabolism remain unclear. Here, we find that LSECs are involved in obesity-associated accumulation of myeloid cells via VLA-4-dep  ...[more]

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