Genomics

Dataset Information

353

Mus musculus


ABSTRACT: EPOP interacts with Elongin BC and USP7 to modulate the chromatin landscape (USP7 KO)

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA339055 | ENA |

REPOSITORIES: ENA

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Publications

EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin Landscape.

Liefke Robert R   Karwacki-Neisius Violetta V   Shi Yang Y  

Molecular cell 20161101 4


Gene regulatory networks are pivotal for many biological processes. In mouse embryonic stem cells (mESCs), the transcriptional network can be divided into three functionally distinct modules: Polycomb, Core, and Myc. The Polycomb module represses developmental genes, while the Myc module is associated with proliferative functions, and its mis-regulation is linked to cancer development. Here, we show that, in mESCs, the Polycomb repressive complex 2 (PRC2)-associated protein EPOP (Elongin BC and  ...[more]

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