Genomics

Dataset Information

138

Homo sapiens


ABSTRACT: Bisphenol A-associated alterations in genome-wide DNA methylation and gene expression patterns reveal sequence-dependent and non-monotonic effects in human fetal liver

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA339106 | ENA |

REPOSITORIES: ENA

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Publications

Bisphenol A-associated alterations in genome-wide DNA methylation and gene expression patterns reveal sequence-dependent and non-monotonic effects in human fetal liver.

Faulk Christopher C   Kim Jung H JH   Jones Tamara R TR   McEachin Richard C RC   Nahar Muna S MS   Dolinoy Dana C DC   Sartor Maureen A MA  

Environmental epigenetics 20150101 1


Bisphenol A (BPA), a high production volume chemical widely used in consumer products, is an endocrine active compound associated with complex epigenetic responses in animal models and humans. Developmental BPA exposure in mice previously revealed widespread changes in the mouse liver methylome. Here, we undertake the first epigenome-wide analysis of the effect of BPA concentration on human fetal liver DNA methylation. Enzymatic enrichment of genomic DNA for high CG density and methylation follo  ...[more]

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